Inhibition of Certain Deoxyribonucleic Acid
نویسندگان
چکیده
A proteinaceous substance was detected in the liver of several animal species that inhibited the multiplication of certain deoxyribonucleic acid, but not ribonucleic acid, viruses. Preliminary experiments suggested that its site of action was not extracellular. It did not inhibit virus by interfering with adsorption to cells. It was suggested that this inhibiting substance acts directly upon cells by interfering with viral synthesis.
منابع مشابه
Inhibition of certain deoxyribonucleic acid viruses by liver extracts.
A proteinaceous substance was detected in the liver of several animal species that inhibited the multiplication of certain deoxyribonucleic acid, but not ribonucleic acid, viruses. Preliminary experiments suggested that its site of action was not extracellular. It did not inhibit virus by interfering with adsorption to cells. It was suggested that this inhibiting substance acts directly upon ce...
متن کاملInhibition of host deoxyribonucleic acid synthesis by T4 bacteriophage in the absence of protein synthesis.
The requirement for phage protein synthesis for the inhibition of host deoxyribonucleic acid synthesis has been investigated by using a phage mutant unable to catalyze the production of any phage deoxyribonucleic acid. It has been concluded that the major pathway whereby phage inhibit host syntheses requires protein synthesis. The inhibition of host syntheses by phage ghosts is not affected by ...
متن کاملThiol Groups in Deoxyribonucleic Acid Nucleotidyltransferase.
1. The inhibitory effects of iodoacetate, iodoacetamide, p-hydroxymercuribenzoate and sarkomycin were studied in a partially purified preparation of deoxyribonucleic acid nucleotidyltransferase from Landschutz ascites-tumour cells. All of these agents inhibited the activity of the enzyme, and it was shown that the inhibition exerted by the last three compounds obeyed non-competitive kinetics. 2...
متن کاملrecA gene product is responsible for inhibition of deoxyribonucleic acid synthesis after ultraviolet irradiation.
Deoxyribonucleic acid synthesis after ultraviolet irradiation was studied in wild-type, uvrA, recB, recA recB, and recA Escherichia coli strains. Inhibition of deoxyribonucleic acid synthesis, which occurs almost immediately after exposing the cells to ultraviolet radiation, depends on the functional gene recA.
متن کاملEffect of Helium-Neon Laser and Sodium Hypochlorite on Calf Thymus Double-Stranded Deoxyribonucleic Acid Molecule: An in Vitro Experimental Study
Introduction: Low-energy helium-neon (He-Ne) laser beam lightis used in combination with sodium hypochlorite (Na2HOCl3) for clinical purposes. Regarding this, the present study aimed to investigate the effect of He-Ne laser (632.8 nm) and sodium hypochlorite on the calf thymus double-stranded deoxyribonucleic acid (ctdsDNA) molecule. Materials and Methods: For the purpose of the study, ctdsDNA...
متن کامل